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顶部生物活性储存和溶解信息计算器

Anti-ADAMTS4 Polyclonal Antibody

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Anti-ADAMTS4 Polyclonal Antibody
产品编号 TMAB-00056
别名 KIAA0688, Aggrecanase-1, ADMP-1, ADAMTS-4, ADAM-TS4, ADAMTS4, ADAM-TS 4, A disintegrin and metalloproteinase with thrombospondin motifs 4

Anti-ADAMTS4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ADAMTS4。Anti-ADAMTS4 Polyclonal Antibody 可用于 WB。

Anti-ADAMTS4 Polyclonal Antibody

Anti-ADAMTS4 Polyclonal Antibody

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Anti-ADAMTS4 Polyclonal Antibody
产品编号 TMAB-00056 别名 KIAA0688, Aggrecanase-1, ADMP-1, ADAMTS-4, ADAM-TS4, ADAMTS4, ADAM-TS 4, A disintegrin and metalloproteinase with thrombospondin motifs 4

Anti-ADAMTS4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ADAMTS4。Anti-ADAMTS4 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-ADAMTS4 Polyclonal Antibody is a Rabbit antibody targeting ADAMTS4. Anti-ADAMTS4 Polyclonal Antibody can be used in WB.
疾病造模方案
别名KIAA0688, Aggrecanase-1, ADMP-1, ADAMTS-4, ADAM-TS4, ADAMTS4, ADAM-TS 4, A disintegrin and metalloproteinase with thrombospondin motifs 4
Ig Type
IgG
交叉反应
Human,Mouse,Rat (predicted:Cow,Rabbit,Sheep)
验证活性
Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Rat Cerebrum tissue lysates
Lane 3: Human A549 cell lysates
Primary: Anti-ADAMTS4 (TMAB-00056) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 90 kDa
Observed band size: 100 kDa
应用
WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted. extracellular space. extracellular matrix.
组织特异性Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
抗原信息
免疫原
KLH conjugated synthetic peptide: human ADAMTS4
抗原种属
Human
基因名称
ADAMTS4
基因ID
9507
蛋白名称
A disintegrin and metalloproteinase with thrombospondin motifs 4
Uniprot ID
O75173
研究领域
MMP,ADAM Protein Family,ADAM TS,ADAM protein family
功能
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
-Ala-393' site.
化学信息
分子量Theoretical: 90 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

KIAA 0688Aggrecanase1ADMP1ADAMTS 4

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