Uridine triacetate

Name: Uridine triacetate
Brand: TargetMol
SKU: T21327
Price: 123 CNY
Availability: InStock
Rating: 5 (10 reviews)

还可以

产品编号 T21327Cas号 4105-38-8

别名 尿苷三乙酸酯, Tri-O-acetyluridine, RG2133 triacetate, RG-2133, RG2133, RG 2133 triacetate, RG 2133, PN-401, PN401, PN 401

Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性，或早发性心脏或中枢神经系统 (CNS) 毒性。

Uridine triacetate

还可以

纯度: 99.89%

产品编号 T21327 别名 尿苷三乙酸酯, Tri-O-acetyluridine, RG2133 triacetate, RG-2133, RG2133, RG 2133 triacetate, RG 2133, PN-401, PN401, PN 401Cas号 4105-38-8

规格	价格	库存
50 mg	¥ 123	In stock
100 mg	¥ 163	In stock
500 mg	¥ 359	In stock
1 g	¥ 518	In stock
5 g	¥ 1,260	In stock
1 mL x 10 mM (in DMSO)	¥ 138	In stock

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Uridine triacetate 相关产品

产品介绍

生物活性

产品描述	Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized in the research of 5-fluorouracil (5-FU) and capecitabine toxicity, particularly targeting early-onset cardiac or central nervous system (CNS) complications.
体外活性	Uridine triacetate inhibits [3H]uridine uptake in ENT1 and ENT2 overexpressed HeLa cells, with IC50s of 28.4 μM and 228.4 μM respectively[4].
体内活性	Uridine triacetate (2 g/kg, oral gavage, every 8 h for 15 total doses) improves survival and reduced toxicity in 5-FU overdose mice. Uridine triacetate (2 g/kg, oral gavage, every 8 h for 15 total doses) improves survival and reduced 5-FU toxicity in DPD deficiency mice[3].
别名	尿苷三乙酸酯, Tri-O-acetyluridine, RG2133 triacetate, RG-2133, RG2133, RG 2133 triacetate, RG 2133, PN-401, PN401, PN 401

化学信息

分子量	370.31
分子式	C₁₅H₁₈N₂O₉
CAS No.	4105-38-8
Smiles	CC(=O)OCC1OC(C(OC(C)=O)C1OC(C)=O)N1C=CC(=O)NC1=O
密度	1.43 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: Insoluble

DMSO: 90 mg/mL (243.04 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7004 mL	13.5022 mL	27.0044 mL	135.0220 mL
5 mM	0.5401 mL	2.7004 mL	5.4009 mL	27.0044 mL
10 mM	0.2700 mL	1.3502 mL	2.7004 mL	13.5022 mL
20 mM	0.1350 mL	0.6751 mL	1.3502 mL	6.7511 mL
50 mM	0.0540 mL	0.2700 mL	0.5401 mL	2.7004 mL
100 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3502 mL