Amylin (1-37), human acetate (hIAPP (1-37), acetate), a peptide hormone containing 37 amino acids secreted by the pancreas in conjunction with insulin, inhibits glucagon secretion and produces satiety during glucose homeostasis, and is a major component of amyloid deposits in the pancreas of patients with type 2 diabetes.

研究中将选定药理伴侣与 Amylin (1-37), human acetate 联合溶解后腹腔注射入 hIAPP 转基因小鼠，连续给药 5 天。与单独注射 hIAPP 的对照组相比，B 和 E 组小鼠胰岛中淀粉样沉积明显减少，胰岛细胞结构更完整，胰岛素免疫反应增强，提示这些伴侣可在体内有效抑制 hIAPP 引起的胰岛毒性[1]。