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Anti-S6K1/RPS6KB1 Antibody (9X665)
还可以产品编号 TMAH-01054
别名 STK14A, S6K-β-1, S6K-beta-1, S6K1, S6K, RPS6KB1, ribosomal protein S6 kinase, polypeptide 1, PS6K, p70-α, p70-S6K, p70-alpha, p70(S6K)-α, p70(S6K)-alpha, p70 S6KA
Anti-S6K1/RPS6KB1 Antibody (9X665) 是一种抗体，靶向 S6K1/RPS6KB1。Anti-S6K1/RPS6KB1 Antibody (9X665) 可用于 ELISA, IF。
Anti-S6K1/RPS6KB1 Antibody (9X665)
Anti-S6K1/RPS6KB1 Antibody (9X665)
还可以产品编号 TMAH-01054 别名 STK14A, S6K-β-1, S6K-beta-1, S6K1, S6K, RPS6KB1, ribosomal protein S6 kinase, polypeptide 1, PS6K, p70-α, p70-S6K, p70-alpha, p70(S6K)-α, p70(S6K)-alpha, p70 S6KA
Anti-S6K1/RPS6KB1 Antibody (9X665) 是一种抗体，靶向 S6K1/RPS6KB1。Anti-S6K1/RPS6KB1 Antibody (9X665) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-S6K1/RPS6KB1 Antibody (9X665) is an antibody targeting S6K1/RPS6KB1. Anti-S6K1/RPS6KB1 Antibody (9X665) can be used in ELISA, IF. |
| 别名 | STK14A, S6K-β-1, S6K-beta-1, S6K1, S6K, RPS6KB1, ribosomal protein S6 kinase, polypeptide 1, PS6K, p70-α, p70-S6K, p70-alpha, p70(S6K)-α, p70(S6K)-alpha, p70 S6KA |
| Ig Type | Rabbit IgG |
| 克隆号 | 9X665 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of Hela Cells with TMAH-01054 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| 应用 | ELISA, IF |
| 推荐剂量 | IF:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell junction, synapse, synaptosome. Mitochondrion outer membrane. Mitochondrion. Note=Colocalizes with URI1 at mitochondrion.; [Isoform Alpha I]: Nucleus. Cytoplasm.; [Isoform Alpha II]: Cytoplasm. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human P70 S6 Kinase alpha |
| 抗原种属 | Human |
| 基因ID | 6198 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Cell biology, Metabolism, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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