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FGFR2IIIc Protein, Human, Recombinant (hFc)

FGFR2IIIc Protein, Human, Recombinant (hFc)

产品编号 TMPJ-00388
别名: FGFR2, FGFR2 beta, FGFR2 β, CD332, FGF R2b, BEK, FGFR2IIIc, FGFR2b

FGFR2IIIc Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802.

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FGFR2IIIc Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 550 5日内发货
50 μg ¥ 1,670 5日内发货
500 μg ¥ 13,700 5日内发货
1 mg ¥ 20,500 5日内发货
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产品目录号及名称: FGFR2IIIc Protein, Human, Recombinant (hFc) (TMPJ-00388)
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产品描述 FGFR2IIIc Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 P21802
别名 FGFR2, FGFR2 beta, FGFR2 β, CD332, FGF R2b, BEK, FGFR2IIIc, FGFR2b
氨基酸序列 Arg22-Glu377
蛋白构建 Arg22-Glu377
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
分子量 85-120 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGF R3 and FGF R4. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

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Keywords

FGFR2IIIc Protein, Human, Recombinant (hFc) FGFR-2 FGFR2 FGFR2 beta CD-332 FGFR2 β CD 332 CD332 FGF R2b BEK, FGFR2IIIc FGFR 2 FGFR2b recombinant recombinant-proteins proteins protein

 

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