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Anti-MMP-9 Antibody (7O176)
还可以产品编号 TMAY-03732
Anti-MMP-9 Antibody (7O176) 是一种 Mouse 抗体，靶向 MMP-9。Anti-MMP-9 Antibody (7O176) 可用于 ELISA(Cap)。
Anti-MMP-9 Antibody (7O176)
Anti-MMP-9 Antibody (7O176)
还可以产品编号 TMAY-03732
Anti-MMP-9 Antibody (7O176) 是一种 Mouse 抗体，靶向 MMP-9。Anti-MMP-9 Antibody (7O176) 可用于 ELISA(Cap)。
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抗原信息
| 产品描述 | Anti-MMP-9 Antibody (7O176) is a Mouse antibody targeting MMP-9. Anti-MMP-9 Antibody (7O176) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 7O176 |
| 交叉反应 | Rat |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat MMP9/MMP-9/CLG4B (rR MMP9/MMP-9/CLG4B; TMPY-02054; EDL96479.1; Met1-Pro708). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| 研究背景 | Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and some transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodeling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. Since the integrity of the tissue architecture is closely dependent on the delicate balance between MMPs and their inhibitors, excessive production of MMP-9 is linked to tissue damage and degenerative inflammatory disorders. As a consequence, regulation of gene transcription and tissue-specific expression of MMP-9 in normal and diseased states are being actively investigated to pave the way for new therapeutic targets. Besides, the dramatic overexpression of MMP-9 in cancer and various inflammatory conditions points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Rat MMP9/MMP-9/CLG4B Protein (TMPY-02054) |
| 抗原种属 | Rat |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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