Anti-P4HB Antibody (1Y42)

Name: Anti-P4HB Antibody (1Y42)
Brand: TargetMol
SKU: TMAY-01235
Rating: 4.5 (1 reviews)

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产品编号 TMAY-01235

别名 Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59

Anti-P4HB Antibody (1Y42) 是一种 Mouse 抗体，靶向 P4HB。Anti-P4HB Antibody (1Y42) 可用于 ELISA,ELISA(Det),IHC-P。

Anti-P4HB Antibody (1Y42)

还可以

产品编号 TMAY-01235 别名 Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59

Anti-P4HB Antibody (1Y42) 是一种 Mouse 抗体，靶向 P4HB。Anti-P4HB Antibody (1Y42) 可用于 ELISA,ELISA(Det),IHC-P。

规格	价格	库存	数量
20 μL	¥ 580	5日内发货
100 μL	¥ 1,694	5日内发货

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生物活性

产品描述	Anti-P4HB Antibody (1Y42) is a Mouse antibody targeting P4HB. Anti-P4HB Antibody (1Y42) can be used in ELISA,ELISA(Det),IHC-P.
别名	Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59
Ig Type	Mouse IgG1
克隆号	1Y42
交叉反应	Human
验证活性	1. Immunochemical staining of human P4HB in human small intestine with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human P4HB in human liver with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human P4HB in human brain with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections).
应用	ELISA,ELISA(Det),IHC-P
推荐剂量	ELISA: 1:1000-1:2000; IHC-P: 1:20-1:80; ELISA(Det): 1:1000-1:10000
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human P4HB / ERBA2L (rh P4HB; TMPY-01012; NP_000909.2; Met 1-Lys 505). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp12 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

偶联与修饰

偶联	Unconjugated
其他可选修饰符	HRP
可提供抗体种类	2

抗原信息

免疫原	Recombinant Protein: Human P4HB protein (TMPY-01012)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.