Name: SIRP beta 2 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-01160
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 243

6-8日内发货

10 μg

¥ 380

6-8日内发货

20 μg

¥ 596

5日内发货

50 μg

¥ 1,170

5日内发货

100 μg

¥ 2,090

5日内发货

200 μg

¥ 3,850

5日内发货

500 μg

¥ 8,600

5日内发货

1 mg

¥ 12,800

5日内发货

生物活性

产品描述	Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.
生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.
种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q5JXA9
氨基酸序列	Gln33-Gly287
蛋白构建	Gln33-Gly287
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	SIRP-β-2, SIRPG, SIRP-beta-2, SIRP β2, SIRP beta 2, Signal-Regulatory Protein β-2, Signal-Regulatory Protein β2, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Beta 2, PTPNS1L3, PTPN1L, dJ776F14.2
内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.

化学信息

分子量	80-95 KDa (reducing condition)

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

SIRP beta 2 Protein, Human, Recombinant (hFc)

SIRP beta 2 Protein, Human, Recombinant (hFc)

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