Poly(styrenyl acetal trehalose) (pSAT) is synthesized by linking trehalose side chains to a polystyrene backbone through acetal bonds. This compound stabilizes various proteins and enzymes against temperature fluctuations without triggering an innate immune response. Additionally, Poly(styrenyl acetal trehalose) can be utilized in synthesizing protein-polymer conjugates, thereby reducing the renal clearance of active molecules.