Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 3,045 | 待询 | ||
5 mg | ¥ 6,447 | 待询 | ||
10 mg | ¥ 9,687 | 待询 |
产品描述 | NHC-diphosphate, a phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its diphosphate form[1], serves as a potent antiviral agent. As a pyrimidine ribonucleoside, NHC effectively counters the replication of Venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV), and hepatitis C virus (HCV)[1]. |
体外活性 | Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate can be observed, while NHC-triphosphate remains the most abundant metabolite.[1]. |
分子量 | 419.176 |
分子式 | C9H15N3O12P2 |
CAS No. | 39023-73-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 160 mg/mL (381.70 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.3856 mL | 11.9282 mL | 23.8563 mL | 59.6408 mL |
5 mM | 0.4771 mL | 2.3856 mL | 4.7713 mL | 11.9282 mL | |
10 mM | 0.2386 mL | 1.1928 mL | 2.3856 mL | 5.9641 mL | |
20 mM | 0.1193 mL | 0.5964 mL | 1.1928 mL | 2.982 mL | |
50 mM | 0.0477 mL | 0.2386 mL | 0.4771 mL | 1.1928 mL | |
100 mM | 0.0239 mL | 0.1193 mL | 0.2386 mL | 0.5964 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NHC-diphosphate 39023-73-9 NHCdiphosphate NHC diphosphate Inhibitor inhibitor inhibit