3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy compounds. This enzyme significantly contributes to the inactivation of the androgen DHT by converting it into 3α-androstanediol, which exhibits reduced androgen activity. Such conversions are crucial in hirsutism research [1].