Name: Integrin alpha V beta 8 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-05717
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 562

3日内发货

10 μg

¥ 918

3日内发货

20 μg

¥ 1,520

3日内发货

50 μg

¥ 2,970

3日内发货

100 μg

¥ 5,120

现货

200 μg

¥ 9,030

5日内发货

500 μg

¥ 19,000

5日内发货

生物活性

产品描述	Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This mechanism differs from that of alpha V beta 6; the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms.
生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This mechanism differs from that of alpha V beta 6; the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P06756&P26012
蛋白构建	A DNA sequence encoding the extracellular domain (Met1-Val992) of human ITGAV (P06756) was fused with a C-terminal polyhistidine tag was expressed., constructed the plasmid 1; A DNA sequence encoding the extracellular domain (Met1-Arg684) of human ITGB8 (P26012) constructed the plasmid 2. The two plasmids were co-expressed and the human ITGAV&ITGB8 heterodimer was purified. Predicted N terminal: Phe31 & Glu43
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
别名	Integrin α V β 8, Integrin alpha V β8
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.