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Anti-AACS Antibody (5F846)
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产品编号 TMAY-01659
别名 SUR-5, ACSF1, acetoacetyl-CoA synthetase
Anti-AACS Antibody (5F846) 是一种 Mouse 抗体，靶向 AACS。Anti-AACS Antibody (5F846) 可用于 ELISA。
Anti-AACS Antibody (5F846)
331 Anti-AACS Antibody (5F846)
还可以产品编号 TMAY-01659 别名 SUR-5, ACSF1, acetoacetyl-CoA synthetase
Anti-AACS Antibody (5F846) 是一种 Mouse 抗体，靶向 AACS。Anti-AACS Antibody (5F846) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-AACS Antibody (5F846) is a Mouse antibody targeting AACS. Anti-AACS Antibody (5F846) can be used in ELISA. |
| 别名 | SUR-5, ACSF1, acetoacetyl-CoA synthetase |
| Ig Type | Mouse IgG2b |
| 克隆号 | 5F846 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human AACS (rh AACS; TMPY-01427; NP_076417.2; Met 1-Phe 672).The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography . |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. It had been improved that Acetoacetyl-CoA Synthetase is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies, was found to be highly expressed in mouse adipose tissue, and GC box and C/EBPs motif were crucial for AACS promoter activity in 3T3-L1 adipocytes. Moreover, AACS promoter activity was controlled mainly by C/EBPalpha during adipogenesis. AACS gene expression is particularly abundant in white adipose tissue, as it is induced during adipocyte differentiation. The human AACS promoter is a PPARgamma target gene and that this nuclear receptor is recruited to the AACS promoter by direct interaction with Sp1 (stimulating protein-1). The Acetoacetyl-CoA Synthetase has important roles in the regulation of ketone body utilization in rat liver and that these hypocholesterolemic agents have the ability to remedy the impaired utilization of ketone bodies under the diabetic condition. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human AACS protein (TMPY-01427) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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