store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet.[3],[4] Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl taurine.[4] In humans, MDCA is rapidly absorbed and is metabolized as an endogenous bile acid with a half-life of approximately 3.5 days.[5]
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,620 | 现货 | ||
5 mg | ¥ 7,210 | 35日内发货 | ||
10 mg | ¥ 12,700 | 35日内发货 |
产品描述 | Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet.[3],[4] Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl taurine.[4] In humans, MDCA is rapidly absorbed and is metabolized as an endogenous bile acid with a half-life of approximately 3.5 days.[5] |
分子量 | 392.57 |
分子式 | C24H40O4 |
CAS No. | 668-49-5 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 30 mg/mL
Ethanol: 20 mg/mL
DMSO: 20 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Murideoxycholic Acid 668-49-5 Inhibitor inhibitor inhibit