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Anti-SCGN Antibody (4D147)
还可以产品编号 TMAY-02340
别名 setagin, SEGN, secretagogin, EF-hand calcium binding protein, SECRET, DJ501N12.8, CALBL
Anti-SCGN Antibody (4D147) 是一种 Mouse 抗体，靶向 SCGN。Anti-SCGN Antibody (4D147) 可用于 IHC-P。
Anti-SCGN Antibody (4D147)
Anti-SCGN Antibody (4D147)
还可以产品编号 TMAY-02340 别名 setagin, SEGN, secretagogin, EF-hand calcium binding protein, SECRET, DJ501N12.8, CALBL
Anti-SCGN Antibody (4D147) 是一种 Mouse 抗体，靶向 SCGN。Anti-SCGN Antibody (4D147) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-SCGN Antibody (4D147) is a Mouse antibody targeting SCGN. Anti-SCGN Antibody (4D147) can be used in IHC-P. |
| 别名 | setagin, SEGN, secretagogin, EF-hand calcium binding protein, SECRET, DJ501N12.8, CALBL |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4D147 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human SCGN in human pancreas with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SCGN / Secretagogin (rh SCGN / Secretagogin; TMPY-01875; NP_008929.2; Asp2-Pro276). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin / SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin / SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin / SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin / SCGN is also a novel marker for neuroendocrine differentiation. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human SCGN / Secretagogin protein (TMPY-01875) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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