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BACE2 Protein, Mouse, Recombinant (His)

Synonyms: β-site APP-cleaving enzyme 2, DRAP, CEAP1, CDA13, beta-site APP-cleaving enzyme 2, BAE2, ASP21, ARP1, ALP56, AI850424, AEPLC, 1110059C24Rik
货号 TMPY-03065 一键复制产品信息
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BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

BACE2 Protein, Mouse, Recombinant (His)

一键复制产品信息
Rating icon 还可以
SPR兼容缓冲液
货号 TMPY-03065

别名 β-site APP-cleaving enzyme 2, DRAP, CEAP1, CDA13, beta-site APP-cleaving enzyme 2, BAE2, ASP21, ARP1, ALP56, AI850424, AEPLC, 1110059C24Rik

BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

BACE2 Protein, Mouse, Recombinant (His)
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规格价格库存数量
5 μg
¥ 555
6-8日内发货
10 μg
¥ 913
6-8日内发货
20 μg
¥ 1,520
5日内发货
50 μg
¥ 2,950
5日内发货
100 μg
¥ 5,880
5日内发货
200 μg
¥ 8,630
5日内发货
500 μg
¥ 17,300
5日内发货
1 mg
¥ 33,700
5日内发货
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产品介绍

生物活性
产品描述
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
生物活性
Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 . The specific activity is >50 pmoles/min/μg.
研究背景
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
种属
Mouse
表达系统
HEK293 Cells
标签C-His
蛋白编号Q9JL18
蛋白构建A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Ala 20
蛋白纯度
> 90 % as determined by SDS-PAGE
蛋白性状Lyophilized powder
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名β-site APP-cleaving enzyme 2, DRAP, CEAP1, CDA13, beta-site APP-cleaving enzyme 2, BAE2, ASP21, ARP1, ALP56, AI850424, AEPLC, 1110059C24Rik
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量49.2 kDa (predicted); 55 kDa (reducing condition, due to glycosylation)
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

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关键词

CEAP-1CEAP 1CDA-13CDA 13b-site APP-cleaving enzyme 2BAE-2BAE 2ASP-21ASP 21ARP-1ARP 1ALP-56ALP 56AI-850424AI 850424
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