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Anti-Osteopontin Antibody (4H276)
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产品编号 TMAY-00674
别名 secreted phosphoprotein 1, OPN, ETA-1, BSPI, BNSP
Anti-Osteopontin Antibody (4H276) 是一种 Rabbit 抗体，靶向 Osteopontin。Anti-Osteopontin Antibody (4H276) 可用于 ELISA,IHC-P,FCM。
Anti-Osteopontin Antibody (4H276)
Anti-Osteopontin Antibody (4H276)
还可以产品编号 TMAY-00674 别名 secreted phosphoprotein 1, OPN, ETA-1, BSPI, BNSP
Anti-Osteopontin Antibody (4H276) 是一种 Rabbit 抗体，靶向 Osteopontin。Anti-Osteopontin Antibody (4H276) 可用于 ELISA,IHC-P,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 780 | 5日内发货 | |
| 100 μL | ¥ 2,289 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Osteopontin Antibody (4H276) is a Rabbit antibody targeting Osteopontin. Anti-Osteopontin Antibody (4H276) can be used in ELISA,IHC-P,FCM. |
| 别名 | secreted phosphoprotein 1, OPN, ETA-1, BSPI, BNSP |
| Ig Type | Rabbit IgG |
| 克隆号 | 4H276 |
| 交叉反应 | Human |
| 验证活性 | 1. Flow cytometric analysis of purified anti-human Spp1 on U937 cells. U937 cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and stained with Purified Rabbit anti-Spp1 (Bold line hisgram), To demonstrate specificity of staining the binding of anti-human Spp1 was blocked by the preincubation of the purified antibody with molar excess of recombinant human Spp1 (5 µg) for 1 hour (dashed line hisgram), then stained with a FITC-conjugated second step antibody. 2. Immunochemical staining of human SPP1 in human kidney with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human SPP1 in human hepatoma with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| 应用 | |
| 推荐剂量 | ELISA: 1:5000-1:10000; IHC-P: 1:1000-1:4000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Osteopontin / SPP1 / ETA-1 (rh Osteopontin / SPP1 / ETA-1; TMPY-01288; NP_001035147.1; Met 1-Asn 314). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Osteopontin, also known as Secreted phosphoprotein 1, Bone sialoprotein 1, BSP-1, OPN, and SPP1, is a member of the osteopontin family and a SIBLING glycoprotein. Osteopontin has been classified as T-helper 1 cytokine and thus believed to exacerbate inflammation in several chronic inflammatory diseases, including atherosclerosis. Besides proinflammatory functions, physiologically Osteopontin is a potent inhibitor of mineralization, it prevents ectopic calcium deposits and is a potent inducible inhibitor of vascular calcification. Osteopontin is expressed and secreted by various cells, and has a role in cell adhesion, chemotaxis, prevention of apoptosis, invasion, migration and anchorage-independent growth of tumor cells. Osteopontin recruitment functions of inflammatory cells are thought to be mediated through its adhesive domains, especially the arginine-glycine-aspartate (RGD) sequence that interacts with several integrin heterodimers. Osteopontin has emerged as a potential biomarker and mediator in cardiovascular disease. In the context of atherosclerosis, OPN is generally regarded as a proinflammatory and proatherogenic molecule. However, the role of OPN in vascular calcification (VC), which is closely related to chronic and active inflammation, is that of a negative regulator because it is an inhibitor of calcification and an active inducer of decalcification. Extensive research has demonstrated the pivotal participation of Osteopontin in the regulation of cell signaling which controls neoplastic and malignant transformation. The elevated expression of Osteopontin has been observed in a variety of cancers. It has been linked with tumor metastasis and signifies a poor prognosis for the patient. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Osteopontin / SPP1 / ETA-1 protein (TMPY-01288) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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