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Anti-OST-beta Polyclonal Antibody

货号 TMAB-09817 一键复制产品信息
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Anti-OST-beta Polyclonal Antibody 是一种 Rabbit 抗体，靶向 OST-beta。Anti-OST-beta Polyclonal Antibody 可用于 WB。

Anti-OST-beta Polyclonal Antibody

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货号 TMAB-09817

Anti-OST-beta Polyclonal Antibody 是一种 Rabbit 抗体，靶向 OST-beta。Anti-OST-beta Polyclonal Antibody 可用于 WB。

Anti-OST-beta Polyclonal Antibody
规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-OST-beta Polyclonal Antibody is a Rabbit antibody targeting OST-beta. Anti-OST-beta Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human
验证活性
20 ng rhOST-beta-GST protein per lane probed with OST-beta polyclonal antibody respectively, unconjugated (TMAB-09817) at 1:1000 dilution and 4°C overnight incubation. Followed by corresponding conjugated secondary antibody incubation at r. T. for 60 min.
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Mainly restricted to the lateral and basal membranes of ileal enterocytes.
组织特异性Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
抗原信息
免疫原
Recombinant Protein: human OST-beta protein
抗原种属
Human
基因名称
SLC51B
基因ID
123264
蛋白名称
Organic solute transporter subunit beta
Uniprot ID
Q86UW2
功能
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
化学信息
分子量Theoretical: 14 kDa. Actual: 35 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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