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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-OST beta Polyclonal Antibody

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货号 TMAB-01292

别名 Ostbeta, OSTB, Ost beta, Organic solute transporter subunit beta, organic solute transporter beta(Ostbeta)

Anti-OST beta Polyclonal Antibody 是一种 Rabbit 抗体，靶向 OST beta。Anti-OST beta Polyclonal Antibody 可用于 ELISA,IF,IHC-Fr,IHC-P。

Anti-OST beta Polyclonal Antibody

Anti-OST beta Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-01292 别名 Ostbeta, OSTB, Ost beta, Organic solute transporter subunit beta, organic solute transporter beta(Ostbeta)

Anti-OST beta Polyclonal Antibody 是一种 Rabbit 抗体，靶向 OST beta。Anti-OST beta Polyclonal Antibody 可用于 ELISA,IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-OST beta Polyclonal Antibody is a Rabbit antibody targeting OST beta. Anti-OST beta Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.
别名Ostbeta, OSTB, Ost beta, Organic solute transporter subunit beta, organic solute transporter beta(Ostbeta)
Ig Type
IgG
反应种属
(predicted:Human,Mouse,Rat)
应用ELISAIFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Mainly restricted to the lateral and basal membranes of ileal enterocytes.
组织特异性Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
抗原信息
免疫原
KLH conjugated synthetic peptide: human OST-beta
抗原种属
Human
基因名称
SLC51B
基因ID
123264
蛋白名称
Organic solute transporter subunit beta
Uniprot ID
Q86UW2
研究领域
Channels
功能
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
化学信息
分子量Theoretical: 14 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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