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Lefty-A Protein, Human, Recombinant (His)
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很棒纯度: 96%
货号 TMPJ-00238
别名 Transforming growth factor β-4, Transforming growth factor beta-4, TGF-β-4, TGF-beta-4, TGFB4, Protein lefty-A, Protein lefty-2, LEFTYA, LEFTY2, Left-right determination factor A, Left-right determination factor 2, LEFTA, Endometrial bleeding-associated factor, EBAF
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name "Lefty". The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding.
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Lefty-A Protein, Human, Recombinant (His)
一键复制产品信息 很棒纯度: 96%
货号 TMPJ-00238 别名 Transforming growth factor β-4, Transforming growth factor beta-4, TGF-β-4, TGF-beta-4, TGFB4, Protein lefty-A, Protein lefty-2, LEFTYA, LEFTY2, Left-right determination factor A, Left-right determination factor 2, LEFTA, Endometrial bleeding-associated factor, EBAF
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name "Lefty". The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 148 | 现货 | |
| 10 μg | ¥ 220 | 现货 | |
| 20 μg | ¥ 353 | 现货 | |
| 50 μg | ¥ 700 | 现货 | |
| 100 μg | ¥ 1,220 | 5日内发货 | |
| 200 μg | ¥ 2,180 | 5日内发货 | |
| 500 μg | ¥ 4,730 | 5日内发货 | |
| 1 mg | ¥ 7,510 | 5日内发货 |
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产品介绍
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化学信息
储存&溶解度
| 产品描述 | Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name "Lefty". The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding. |
| 生物活性 | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| 研究背景 | Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins and that are necessary to form the cysteineknot structure. Its function in patterning left-right asymmetry of the developing organ systems such as the heart and lung is consistent in all vertebrate species examined. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor. It may play a role in endometrial bleeding. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | N-6xHis |
| 蛋白编号 | O00292 |
| 氨基酸序列 | Phe78-Pro366 |
| 蛋白构建 | Phe78-Pro366 |
| 蛋白纯度 | Greater than 90% as determined by reducing SDS-PAGE. (QC verified) |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Histidine-HCl, 4% Sucrose, 4% Mannitol, 0.1% Tween 80, pH6.0. |
| 复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| 别名 | Transforming growth factor β-4, Transforming growth factor beta-4, TGF-β-4, TGF-beta-4, TGFB4, Protein lefty-A, Protein lefty-2, LEFTYA, LEFTY2, Left-right determination factor A, Left-right determination factor 2, LEFTA, Endometrial bleeding-associated factor, EBAF |
| 内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| 分子量 | 45-50 KDa (reducing condition) |
| 颜色 | White |
| 物理性状 | Lyophilized powder |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| 存储 | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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