Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isodeoxycholic Acid 是一种胆汁酸,由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚,这表明它的去污活性降低了,而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid(0.1%)能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发,并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中,血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 578 | 现货 | ||
5 mg | ¥ 1,990 | 现货 | ||
10 mg | ¥ 3,230 | 现货 | ||
25 mg | ¥ 6,230 | 现货 | ||
50 mg | ¥ 8,390 | 现货 | ||
100 mg | ¥ 11,300 | 现货 |
产品描述 | Isodeoxycholic Acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria. It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic Acid(0.1%) inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells. Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. |
体外活性 | Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decrease the cytotoxicity of C. difficile culture supernatants to Vero cells.[3] |
别名 | isoDCA |
分子量 | 392.57 |
分子式 | C24H40O4 |
CAS No. | 566-17-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 27.0 mg/mL (68.8 mM)
Ethanol: 18.0 mg/mL (45.8 mM)
DMSO: 18.0 mg/mL (45.8 mM)
DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMF / Ethanol / DMSO | 1 mM | 2.5473 mL | 12.7366 mL | 25.4732 mL | 63.6829 mL |
5 mM | 0.5095 mL | 2.5473 mL | 5.0946 mL | 12.7366 mL | |
10 mM | 0.2547 mL | 1.2737 mL | 2.5473 mL | 6.3683 mL | |
20 mM | 0.1274 mL | 0.6368 mL | 1.2737 mL | 3.1841 mL | |
DMF | 50 mM | 0.0509 mL | 0.2547 mL | 0.5095 mL | 1.2737 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Isodeoxycholic Acid 566-17-6 Membrane transporter/Ion channel Microbiology/Virology Chloride channel Antibacterial isoDCA Inhibitor inhibitor inhibit