Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norethindrone acetate (19-Norethindroneacetate) 是一种雌性激素,对青少年月经和肝腺瘤有抑制作用,常与孕激素联合使用,可用于研究子宫内膜异位症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 132 | 现货 | ||
50 mg | ¥ 178 | 现货 | ||
100 mg | ¥ 247 | 现货 | ||
500 mg | ¥ 496 | 现货 | ||
1 g | ¥ 723 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 272 | 现货 |
产品描述 | Norethindrone acetate (19-Norethindroneacetate) is an oestrogen with inhibitory effects on adolescent menstruation and hepatic adenomas and is often used in combination with progestins in the study of endometriosis. |
体内活性 |
Norethindrone acetate effectively relieves dysmenorrhea and noncyclic pelvic pain.[1]
Norethindrone acetate as a standalone treatment option demonstrates excellent tolerability and efficacy in managing pain and bleeding associated with all stages of endometriosis.[2] Experimental studies indicate that norethindrone acetate exhibits low acute toxicity in animals. Administration of norethindrone acetate alone to rodents at doses several times higher than those used in humans does not result in treatment-related mortality, hematological changes, behavioral alterations, or organ pathology.[3] Administration of norethindrone acetate leads to significant and proportional reductions in the concentrations of triglycerides, cholesterol, and phospholipids in plasma lipoproteins with a density <1.006 in rats fed a high carbohydrate diet.[4] Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides in isolated hepatocytes obtained from fed rats.[4] |
别名 | 19-Norethindroneacetate |
分子量 | 340.46 |
分子式 | C22H28O3 |
CAS No. | 51-98-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 0.6 mg/mL (1.8 mM ), Sonication is recommended.
DMSO: 90.0 mg/mL (264.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.9372 mL | 14.686 mL | 29.372 mL | 73.4301 mL |
DMSO | 5 mM | 0.5874 mL | 2.9372 mL | 5.8744 mL | 14.686 mL |
10 mM | 0.2937 mL | 1.4686 mL | 2.9372 mL | 7.343 mL | |
20 mM | 0.1469 mL | 0.7343 mL | 1.4686 mL | 3.6715 mL | |
50 mM | 0.0587 mL | 0.2937 mL | 0.5874 mL | 1.4686 mL | |
100 mM | 0.0294 mL | 0.1469 mL | 0.2937 mL | 0.7343 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Norethindrone acetate 51-98-9 Endocrinology/Hormones Others Estrogen Receptor/ERR Progesterone Receptor 19-Norethindroneacetate Norethindrone Acetate Inhibitor inhibitor inhibit