规格

价格

库存

数量

100 ug (337.33 μM* 1 mL in Ethanol)

¥ 3,890

现货

250 ug (337.33 μM * 2.5 mL in Ethanol)

¥ 7,800

现货

500 ug (337.33 μM * 5 mL in Ethanol)

¥ 14,500

现货

生物活性

产品描述	(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid inhibits the adhesion of tumor cells to the vascular endothelium and down-regulates the expression of IRGpIIb/IIIa receptors at around 1 μM. (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX), which often acts as an endogenous ligand to activate PPARγ. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial damage.
体外活性	(S)-Coriolic acid（30 nM; 6 h; E-FABP-/-角质形成细胞）通过NF-κB激活促进K1表达。(S)-Coriolic acid 还增加Ikkinase-bat酪氨酸199的磷酸化，这促进了IκBα的磷酸化和随后的NF-kB激活。(S)-Coriolic acid增加了IκBα在丝氨酸32的磷酸化，这引发了IκB的降解并因此激活了NF-κB。[3]
体内活性	(S)-Coriolic acid (0-0.6 mg; Intranasal; 每天一次，连续三天; 小鼠) 显著诱发气道功能障碍、气道中性粒细胞增多、线粒体功能障碍及上皮细胞损伤。[2]
别名	13(S)-HODE

化学信息

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Ethanol: >50 mg/mL (per Rao Maddipati), Sonication is recommended.

DMSO: 55 mg/mL (185.54 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (3.37 mM), Sonication is recommended.

DMF: >50 mg/mL (per Rao Maddipati), Sonication is recommended.

溶液配制表

PBS (pH 7.2)/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3734 mL	16.8668 mL	33.7336 mL	168.6682 mL

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

(S)-Coriolic acid