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Anti-METAP2 Antibody (5B549)
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还可以产品编号 TMAH-00750
别名 p67eIF2, p67, MNPEP, methionyl aminopeptidase 2, MAP2
Anti-METAP2 Antibody (5B549) 是一种抗体，靶向 METAP2。Anti-METAP2 Antibody (5B549) 可用于 ELISA,IHC。
Anti-METAP2 Antibody (5B549)
Anti-METAP2 Antibody (5B549)
一键复制产品信息 还可以产品编号 TMAH-00750 别名 p67eIF2, p67, MNPEP, methionyl aminopeptidase 2, MAP2
Anti-METAP2 Antibody (5B549) 是一种抗体，靶向 METAP2。Anti-METAP2 Antibody (5B549) 可用于 ELISA,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-METAP2 Antibody (5B549) is an antibody targeting METAP2. Anti-METAP2 Antibody (5B549) can be used in ELISA,IHC. |
| 别名 | p67eIF2, p67, MNPEP, methionyl aminopeptidase 2, MAP2 |
| Ig Type | Rabbit IgG |
| 克隆号 | 5B549 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00750 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISAIHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Methionine Aminopeptidase 2 |
| 抗原种属 | Human |
| 基因名称 | METAP2 |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Metabolism, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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