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Anti-METAP2 Antibody (5B549)

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产品编号 TMAH-00750
别名 p67eIF2, p67, MNPEP, methionyl aminopeptidase 2, MAP2

Anti-METAP2 Antibody (5B549) 是一种抗体,靶向 METAP2。Anti-METAP2 Antibody (5B549) 可用于 ELISA, IHC。

Anti-METAP2 Antibody (5B549)

Anti-METAP2 Antibody (5B549)

Rating icon 还可以
产品编号 TMAH-00750 别名 p67eIF2, p67, MNPEP, methionyl aminopeptidase 2, MAP2

Anti-METAP2 Antibody (5B549) 是一种抗体,靶向 METAP2。Anti-METAP2 Antibody (5B549) 可用于 ELISA, IHC。

规格价格库存数量
50 μL
¥ 1,300
5日内发货
100 μL
¥ 2,190
5日内发货
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产品介绍

生物活性
产品描述
Anti-METAP2 Antibody (5B549) is an antibody targeting METAP2. Anti-METAP2 Antibody (5B549) can be used in ELISA, IHC.
别名p67eIF2, p67, MNPEP, methionyl aminopeptidase 2, MAP2
Ig Type
Rabbit IgG
克隆号
5B549
交叉反应
Human
验证活性
IHC image of TMAH-00750 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用
ELISA, IHC
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Methionine Aminopeptidase 2
抗原种属
Human
基因ID
10988
Uniprot ID
研究领域
Metabolism, Signal transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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