购物车
- 全部删除
- 您的购物车当前为空
Anti-METAP2 Antibody (5B549) 是一种抗体,靶向 METAP2。Anti-METAP2 Antibody (5B549) 可用于 ELISA, IHC。
Anti-METAP2 Antibody (5B549) 是一种抗体,靶向 METAP2。Anti-METAP2 Antibody (5B549) 可用于 ELISA, IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,300 | 5日内发货 | |
100 μL | ¥ 2,190 | 5日内发货 |
产品描述 | Anti-METAP2 Antibody (5B549) is an antibody targeting METAP2. Anti-METAP2 Antibody (5B549) can be used in ELISA, IHC. |
别名 | p67eIF2, p67, MNPEP, methionyl aminopeptidase 2, MAP2 |
Ig Type | Rabbit IgG |
克隆号 | 5B549 |
交叉反应 | Human |
验证活性 | IHC image of TMAH-00750 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
应用 | ELISA, IHC |
推荐剂量 | IHC:1:50-1:200. |
抗体种类 | Monoclonal |
亚细胞定位 | Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes. |
构建方式 | Recombinant Antibody |
纯化方式 | Affinity-chromatography |
性状 | Liquid |
缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
研究背景 | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
偶联 | Unconjugated |
免疫原 | A synthetic peptide: Human Methionine Aminopeptidase 2 |
抗原种属 | Human |
基因ID | 10988 |
Uniprot ID | |
研究领域 | Metabolism, Signal transduction |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
评论内容