Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor.
规格 | 价格/CNY | 货期 | 数量 | |
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50 μg | ¥ 3,820 | 现货 | ||
1 mg | ¥ 22,400 | 5日内发货 |
生物活性 |
Measured by its binding ability in a functional ELISA. Immobilized Human PDGF-B His at 2 μg/ml (100 μl/well) can bind Human PDGFRBHis & hFc, the EC50 of Human PDGFRBHis & hFc is 9.0-40.0 ng/mL.
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产品描述 | Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. |
种属 | Human |
表达系统 | Yeast |
标签 | His |
蛋白编号 | P01127-2 |
别名 | platelet-derived growth factor beta polypeptide, SSV, c-sis, SIS, PDGF-2, IBGC5, PDGF2, platelet-derived growth factor β polypeptide, 血小板源生长因子 |
蛋白构建 | A DNA sequence encoding the human PDGFB (NP_148937.1) (Ser82-Thr190) was expressed with a polyhistidine tag at the N-terminus. |
蛋白纯度 |
> 95 % as determined by SDS-PAGE.
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分子量 | Approxiamtely 14.3 kDa |
内毒素 | < 1.0 EU per μg of the protein as determined by the LAL method. |
缓冲液 | Supplied as sterile PBS, 25 % Glycerol, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA. |
复溶方法 | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
存储 |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
运输方式 |
Solution. It is shipped out with blue ice. |
研究背景 | Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. |
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PDGFB Protein, Human, Recombinant (His) platelet-derived growth factor beta polypeptide SSV c-sis SIS IBGC 5 PDGF-2 IBGC5 PDGF2 PDGF 2 platelet-derived growth factor β polypeptide IBGC-5 血小板源生长因子 platelet-derived growth factor b polypeptide recombinant recombinant-proteins proteins protein