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NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)

NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)

产品编号 TMPJ-00448
别名: NRG1β, HGL, NDF, NRG1, HRGA, HRG1-beta 1, Pro-neuregulin-1, HRG1-β1, SMDF, Neuregulin-1 β 1, EGF, GGF, Neuregulin-1 beta 1, NRG1-beta 1, NRG1-β1

Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

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NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)
规格 价格/CNY 货期 数量
10 μg ¥ 740 5日内发货
50 μg ¥ 1,970 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: NRG1 beta 1 Protein, Human, Recombinant (aa 2-246) (TMPJ-00448)
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技术参数
产品性质
产品描述 Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
种属 Human
表达系统 E. coli
标签 Tag Free
蛋白编号 AAA58639.1
别名 NRG1β, HGL, NDF, NRG1, HRGA, HRG1-beta 1, Pro-neuregulin-1, HRG1-β1, SMDF, Neuregulin-1 β 1, EGF, GGF, Neuregulin-1 beta 1, NRG1-beta 1, NRG1-β1
氨基酸序列 Ser2-Lys246
蛋白构建 Ser2-Lys246
蛋白纯度 Greater than 85% as determined by reducing SDS-PAGE. Greater than 85% as determined by SEC-HPLC.
分子量 34 KDa (reducing condition)
内毒素 < 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

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Keywords

NRG1 beta 1 Protein, Human, Recombinant (aa 2-246) NRG1-β 1 NRG1β HGL NDF NRG1 HRGA HRG1-beta 1 Pro-neuregulin-1 HRG1-β1 SMDF Neuregulin-1 β 1 EGF NRG1-b 1 HRG1-b 1 NRG 1 GGF Neuregulin-1 beta 1 NRG-1 HRG1-β 1 NRG1-beta 1 NRG1-β1 Neuregulin-1 b 1 recombinant recombinant-proteins proteins protein

 

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