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TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated

产品编号 TMPY-05810

别名: RIIC, TAAD2, AAT3, TGFβ-RII, FAA3, transforming growth factor, β receptor II, MFS2, transforming growth factor, beta receptor II (70/80kDa), TGFR-2, LDS2, TGFbeta-RII, LDS1B, LDS2B

TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is P37173.

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TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 2,440		5日内发货
100 μg	￥ 5,810		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is P37173.

种属	Human
表达系统	HEK293 Cells
标签	His, hFc
蛋白编号	P37173
别名	RIIC, TAAD2, AAT3, TGFβ-RII, FAA3, transforming growth factor, β receptor II, MFS2, transforming growth factor, beta receptor II (70/80kDa), TGFR-2, LDS2, TGFbeta-RII, LDS1B, LDS2B
蛋白构建	The extracellular domain (Met1-Asp159) of Human TGFB receptor 2 (NP_003233.4) was expressed with the fused C-terminal His-tagged Fc region of Human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	43.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.

参考文献

1. Yu Y,et al.(2012) MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells. Carcinogenesis. 33(1):68-76. 2. Shima K,et al.(2011) TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PLoS One. 6(9):e25062. 3. Biros E,et al.(2011) Meta-analysis of the association between single nucleotide polymorphisms in TGF-β receptor genes and abdominal aortic aneurysm. Atherosclerosis. 219(1):218-23.

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Keywords

TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated TGFb-RII MFS-2 LDS-2 RIIC TAAD2 TAAD-2 AAT3 70/80kDa FAA-3 TGFβ-RII FAA3 transforming growth factor, β receptor II LDS 2 MFS2 transforming growth factor, beta receptor II transforming growth factor, beta receptor II (70/80kDa) TGFR 2 TGFR2 FAA 3 TGFR-2 TAAD 2 MFS 2 LDS2 TGFbeta-RII AAT 3 LDS1B transforming growth factor, b receptor II AAT-3 LDS2B recombinant recombinant-proteins proteins protein

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