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Anti-FGFR4 Antibody (7B625)
还可以产品编号 TMAH-00436
别名 TKF, JTK2, FGFR4 β, FGFR4 beta, FGFR-4, FGFR4, FGF R4, CD334
Anti-FGFR4 Antibody (7B625) 是一种抗体，靶向 FGFR4。Anti-FGFR4 Antibody (7B625) 可用于 ELISA, IHC。
Anti-FGFR4 Antibody (7B625)
Anti-FGFR4 Antibody (7B625)
还可以产品编号 TMAH-00436 别名 TKF, JTK2, FGFR4 β, FGFR4 beta, FGFR-4, FGFR4, FGF R4, CD334
Anti-FGFR4 Antibody (7B625) 是一种抗体，靶向 FGFR4。Anti-FGFR4 Antibody (7B625) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-FGFR4 Antibody (7B625) is an antibody targeting FGFR4. Anti-FGFR4 Antibody (7B625) can be used in ELISA, IHC. |
| 别名 | TKF, JTK2, FGFR4 β, FGFR4 beta, FGFR-4, FGFR4, FGF R4, CD334 |
| Ig Type | Rabbit IgG |
| 克隆号 | 7B625 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00436 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human FGFR4 |
| 抗原种属 | Human |
| 基因ID | 2264 |
| Uniprot ID | |
| 研究领域 | Neuroscience, Cancer, Cardiovascular, Cell biology, Tags & Cell Markers, Signal transduction, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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