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Anti-ACTH (1-39) Polyclonal Antibody

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货号 TMAB-00051

别名 Proopiomelanocortin, Pro opiomelanocortin, POMC, POC, NPP, MSH, Met Enkephalin, Melanotropin alpha, LPH, Lipotropin gamma, Lipotropin beta, Corticotropin lipotropin precursor, Corticotropin Like Intermediary Peptide, Corticotropin, COLI, CLIP, beta Melanocyte Stimulating Hormone, beta Lipotropin, alpha Melanocyte Stimulating Hormone, Adrenocorticotropin Hormone, Adrenocorticotropin

Anti-ACTH (1-39) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ACTH (1-39)。Anti-ACTH (1-39) Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-ACTH (1-39) Polyclonal Antibody

Anti-ACTH (1-39) Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-00051 别名 Proopiomelanocortin, Pro opiomelanocortin, POMC, POC, NPP, MSH, Met Enkephalin, Melanotropin alpha, LPH, Lipotropin gamma, Lipotropin beta, Corticotropin lipotropin precursor, Corticotropin Like Intermediary Peptide, Corticotropin, COLI, CLIP, beta Melanocyte Stimulating Hormone, beta Lipotropin, alpha Melanocyte Stimulating Hormone, Adrenocorticotropin Hormone, Adrenocorticotropin

Anti-ACTH (1-39) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ACTH (1-39)。Anti-ACTH (1-39) Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-ACTH (1-39) Polyclonal Antibody is a Rabbit antibody targeting ACTH (1-39). Anti-ACTH (1-39) Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名Proopiomelanocortin, Pro opiomelanocortin, POMC, POC, NPP, MSH, Met Enkephalin, Melanotropin alpha, LPH, Lipotropin gamma, Lipotropin beta, Corticotropin lipotropin precursor, Corticotropin Like Intermediary Peptide, Corticotropin, COLI, CLIP, beta Melanocyte Stimulating Hormone, beta Lipotropin, alpha Melanocyte Stimulating Hormone, Adrenocorticotropin Hormone, Adrenocorticotropin
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Cow,Goat)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (Human pituitary tumor); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (ACTH (1-39)) Polyclonal Antibody, Unconjugated (TMAB-00051) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 min and DAB staining.
2. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-ACTh (1-39) Polyclonal Antibody, Unconjugated (TMAB-00051) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
3. Tissue/cell: rat brain tissue;4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-ACTh (1-39) Polyclonal Antibody, Unconjugated (TMAB-00051) 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. DAPI (5 μg/ml,blue) was used to stain the cell nucleus.
verifiedActivityverifiedActivityverifiedActivity
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted.
组织特异性ACTH and MSH are produced by the pituitary gland.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human ACTH
抗原种属
Human
基因名称
POMC
基因ID
5443
蛋白名称
Pro-opiomelanocortin
Uniprot ID
P01189
研究领域
Hormone biosynthesis,Hormone biosynthesis,Hypothalamic pituitary adrenal axis,Hormones,Hormones
功能
ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.
化学信息
分子量Theoretical: 4.5 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

  • 稀释 计算器
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