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Elezanumab(ABT-555) 是一种有效的人抗 RGMa 单克隆抗体。Elezanumab 通过 SMAD1/5/8 通路发挥对 RGMa 介导的 BMP 信号传导的抑制作用,IC50 约为 97 pM。在神经元损伤和脱髓鞘模型中,Elezanumab 促进神经再生、神经保护和神经恢复。Elezanumab 促进皮质脊髓轴突生长为脊髓灰质,并增强腹角的血清素能神经支配,形成颈部病变尾部的突触连接。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,320 | 现货 | ||
5 mg | ¥ 5,970 | 现货 | ||
10 mg | ¥ 7,880 | 现货 | ||
25 mg | ¥ 11,900 | 现货 | ||
50 mg | ¥ 15,900 | 现货 |
产品描述 | Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions. |
体内活性 |
Elezanumab (1-10 mg/kg; IV; weekly; 5 times) promotes axonal regeneration and prevents axonal regeneration in the female Lewis rat model of optic nerve crush and optic neuritis Retinal nerve fiber layer degeneration.[1] Elezanumab (0.01, 0.1, 1, 10 mg/kg; IV; once weekly; 3 times) promotes axonal regeneration in a spine-targeted female Lewis rat model of experimental autoimmune encephalomyelitis (EAE) and remyelination, reducing the area of inflammatory lesions and improving functional recovery.[1] |
别名 | AE12-1Y-QL, ABT-555 |
分子量 | N/A |
CAS No. | 1791416-49-3 |
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对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Elezanumab 1791416-49-3 Stem Cells TGF-beta/Smad AE12-1Y-QL ABT 555 ABT-555 ABT555 Inhibitor inhibitor inhibit