Name: Elezanumab
Brand: TargetMol
SKU: T76863
Price: 1990 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,990

现货

5 mg

¥ 4,970

现货

10 mg

¥ 6,880

现货

25 mg

¥ 9,870

现货

50 mg

¥ 13,700

现货

生物活性

产品描述	Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions.
体内活性	Elezanumab（1-10 mg/kg；静脉注射；每周一次；共5次）在雌性Lewis大鼠的视神经挤压和视神经炎模型中促进轴突再生并防止视网膜神经纤维层退化。[1] Elezanumab（0.01、0.1、1、10 mg/kg；静脉注射；每周一次；共3次）在针对脊髓的雌性Lewis大鼠实验性自身免疫性脑炎（EAE）模型中促进轴突再生和髓鞘再生，减少炎症病灶面积并改善功能恢复。[1]
别名	依来努单抗, AE12-1Y-QL, ABT-555
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
内毒素	< 1.0 EU/mg

抗体信息

同型	IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Elezanumab