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12-oxo Leukotriene B4

12-oxo Leukotriene B4

产品编号 T37256   CAS 136696-10-1
别名: 12-oxo Leukotriene B4

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.

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12-oxo Leukotriene B4 Chemical Structure
12-oxo Leukotriene B4, CAS 136696-10-1
规格 价格/CNY 货期 数量
10 μg ¥ 1,850 35日内发货
25 μg ¥ 3,880 35日内发货
50 μg ¥ 7,240 35日内发货
100 μg ¥ 12,600 35日内发货
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: 12-oxo Leukotriene B4 (T37256)
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产品描述 Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.
别名 12-oxo Leukotriene B4
分子量 334.456
分子式 C20H30O4
CAS No. 136696-10-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: Miscible

PBS (pH 7.2): > 1 mg/mL

DMF: Miscible

DMSO: Miscible

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Keywords

12-oxo Leukotriene B4 136696-10-1 12oxo Leukotriene B4 12 oxo Leukotriene B4 12-oxo Leukotriene B-4 Inhibitor inhibitor inhibit

 

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