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Anti-PGC-1 alpha/PGC-1 beta Antibody (4J642) 是一种 Rabbit 抗体,靶向 PGC-1 alpha/PGC-1 beta。Anti-PGC-1 alpha/PGC-1 beta Antibody (4J642) 可用于 WB。
Anti-PGC-1 alpha/PGC-1 beta Antibody (4J642) 是一种 Rabbit 抗体,靶向 PGC-1 alpha/PGC-1 beta。Anti-PGC-1 alpha/PGC-1 beta Antibody (4J642) 可用于 WB。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,495 | 5日内发货 | |
100 μL | ¥ 2,485 | 5日内发货 |
产品描述 | Anti-PGC-1 alpha/PGC-1 beta Antibody (4J642) is a Rabbit antibody targeting PGC-1 alpha/PGC-1 beta. Anti-PGC-1 alpha/PGC-1 beta Antibody (4J642) can be used in WB. |
别名 | PRGC2, PRGC1, PPARGC-1-beta, Ppargc1b, PPARGC1A, PPARGC1, PPARGC 1 alpha, PPAR-gamma coactivator 1-beta, PPAR-gamma coactivator 1-alpha, PPAR gamma coactivator-1beta, PPAR gamma coactivator variant form, PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6, PPAR gamma coactivator 1 alpha, PPAR gamma coactivator 1, PGC1β, PGC1α, PGC1v, PGC-1-related estrogen receptor alpha coactivator, PGC-1-beta, PGC-1-alpha, PGC1A, PGC-1(beta), PGC1(alpha), PGC1 β, PGC1 α, PGC1, PGC 1v, PGC 1(alpha), peroxisome proliferator-activated receptor gamma coactivator 1 beta, Peroxisome proliferator activated receptor gamma coactivator 1 alpha, Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, Peroxisome proliferative activated receptor, gamma, coactivator 1, PERC, Ligand effect modulator 6, LEM6 |
Ig Type | IgG |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. Western blot analysis of PGC1 alpha+beta on different lysates using anti-PGC1 alpha+beta antibody at 1/1,000 dilution. Positive control: Lane 1: Mouse brain, Lane 2: Mouse heart, Lane 3: Mouse kidney. |
应用 | |
推荐剂量 | WB: 1:1000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Transcription factors exert their effects by associating with co-activator or corepressor proteins. The co-activator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Co-activators include the steroid receptor coactivator (SRC) and CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPARgamma co-activator-1 (PGC-1) is a transcriptional cofactor of nuclear respiratory factor-1 (NRF-1), PPARbeta, PPARalpha and other nuclear receptors that is induced by exposure to cold temperatures and is involved in regulating thermogenic gene expression, protein uncoupling, and mitochondrial biogenesis. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. Docking of PGC-1 to PPARgamma stimulates an apparent conformational change that then enables PGC-1 to bind to and assemble into complexes, which include the additional cofactors SRC-1 and CBP/p300, and results in a large increase in transcriptional activity. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein |
Uniprot ID |
分子量 | Theoretical: 113 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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