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Anti-FMR1 Antibody (9X925)
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产品编号 TMAC-01524
别名 zgc:66226, wu:fd18c10, wu:fb16f11, Protein FMR-1, Protein FMR1, POF1, POF, MGC87458, fxr1, FRAXA, fragile X mental retardation, autosomal homolog 1, fragile X mental retardation syndrome-related protein 1, Fragile X mental retardation protein 1, Fragile X mental retardation protein, Fragile X mental retardation 1 protein, Fragile X mental retardation 1, FMRP, FMR1_HUMAN, Fmr1 gene, Fmr1, FMR 1
Anti-FMR1 Antibody (9X925) 是一种 Rabbit 抗体，靶向 FMR1。Anti-FMR1 Antibody (9X925) 可用于 WB,ICC/IF,IHC。
Anti-FMR1 Antibody (9X925)
Anti-FMR1 Antibody (9X925)
还可以产品编号 TMAC-01524 别名 zgc:66226, wu:fd18c10, wu:fb16f11, Protein FMR-1, Protein FMR1, POF1, POF, MGC87458, fxr1, FRAXA, fragile X mental retardation, autosomal homolog 1, fragile X mental retardation syndrome-related protein 1, Fragile X mental retardation protein 1, Fragile X mental retardation protein, Fragile X mental retardation 1 protein, Fragile X mental retardation 1, FMRP, FMR1_HUMAN, Fmr1 gene, Fmr1, FMR 1
Anti-FMR1 Antibody (9X925) 是一种 Rabbit 抗体，靶向 FMR1。Anti-FMR1 Antibody (9X925) 可用于 WB,ICC/IF,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-FMR1 Antibody (9X925) is a Rabbit antibody targeting FMR1. Anti-FMR1 Antibody (9X925) can be used in WB,ICC/IF,IHC. |
| 别名 | zgc:66226, wu:fd18c10, wu:fb16f11, Protein FMR-1, Protein FMR1, POF1, POF, MGC87458, fxr1, FRAXA, fragile X mental retardation, autosomal homolog 1, fragile X mental retardation syndrome-related protein 1, Fragile X mental retardation protein 1, Fragile X mental retardation protein, Fragile X mental retardation 1 protein, Fragile X mental retardation 1, FMRP, FMR1_HUMAN, Fmr1 gene, Fmr1, FMR 1 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of FMRP on different cells lysates using anti-FMRP antibody at 1/500 dilution. Positive control: Lane 1: Hela, Lane 2: K562. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-FMRP antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-FMRP antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-FMRP antibody. Counter stained with hematoxylin. 5. ICC staining FMRP in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining FMRP in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining FMRP in SH-SY5Y cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:5000-10000; IHC: 1:50-200; ICC/IF: 1:100-500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene. In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, which form heterodimers through their N-terminal coiled-coil domains. Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 71 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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