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6-Thioguanosine

Name: 6-Thioguanosine
Brand: TargetMol
SKU: T20511
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.05%

货号 T20511Cas号 85-31-4

别名 NSC-29422, NSC29422, NSC 29422, 6-硫基鸟嘌呤, 6-Mercaptoguanosine

6-Thioguanosine (6-Mercaptoguanosine) 是一种活性核苷，是 Azathioprine 的代谢物，是低分子量凝胶剂。6-Thioguanosine 具有免疫抑制作用，可用于研究RNA 双螺旋结构的形成。

6-Thioguanosine

一键复制产品信息

很棒

纯度: 97.05%

货号 T20511 别名 NSC-29422, NSC29422, NSC 29422, 6-硫基鸟嘌呤, 6-MercaptoguanosineCas号 85-31-4

规格	价格	库存
50 mg	¥ 163	现货
100 mg	¥ 218	现货
200 mg	¥ 295	现货
1 mL x 10 mM (in DMSO)	¥ 132	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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实验操作小课堂

常见问题解答

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纯度: 97.05%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

6-Thioguanosine AI Summary

6-Thioguanosine exhibits diverse bioactivities across various biological targets and pathways. It shows cytotoxic activity against murine leukemia L1210 cells with an ID50 of 0.1 µM and enhances post-inoculation lifespan in L1210 inoculated mice at a dose of 8.1 mg/kg, with a T/C value of 147.0% and an activity value of 98.41%. It is effective in inhibiting Eimeria tenella growth with an MEC greater than 50.0 mg/l and inhibits Bacillus anthracis Sterne spore germination with a Ki of 98000.0 nM, demonstrating 88.0% inhibition of cytopathic effect in infected mouse RAW264.7 macrophages at 1-2 µM. Additionally, it inhibits germination and cytotoxicity of Bacillus anthracis Sterne 34F2 spores and shows a significant IC50 ratio for spore germination and antibacterial activity. The compound is a potent inhibitor across various targets, including JMJD2A-Tudor Domain, Cancer Stem Cells (AC50 300.7 nM), Histone Lysine Methyltransferase G9a (potency 1778.3 nM), BAZ2B (potency 89125.1 nM), PLK1-PDB (potency 21192.3 nM), and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It shows significant antiviral activity against SARS-CoV-2, with 77.04% inhibition of induced cytotoxicity in Caco-2 cells at 10 µM and an IC50 of 780.0 nM, as well as 99.2% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. However, it shows limited activity against SARS-CoV-2 in VERO-E6 cells with an IC50 of 15590.0 nM. Furthermore, 6-Thioguanosine demonstrates antiproliferative effects against cells with low HGPRT expression and modulates mRNA expression of CCNT1, p21, and ND1 in HEK293T cells. It also has inhibitory effects on human HDAC6, although showing slight negative inhibition with a custom peptide substrate. These varied activities suggest 6-Thioguanosine as a versatile candidate for multiple therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside, a metabolite of Azathioprine, and a low molecular weight gel.6-Thioguanosine is immunosuppressive and has been used to study the formation of the RNA double helix.
别名	NSC-29422, NSC29422, NSC 29422, 6-硫基鸟嘌呤, 6-Mercaptoguanosine

化学信息

分子量	299.31
分子式	C₁₀H₁₃N₅O₄S
CAS No.	85-31-4
Smiles	Nc1nc2n(cnc2c(=S)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
密度	2.18 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 6.88 mg/mL (22.99 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3410 mL	16.7051 mL	33.4102 mL	167.0509 mL
5 mM	0.6682 mL	3.3410 mL	6.6820 mL	33.4102 mL
10 mM	0.3341 mL	1.6705 mL	3.3410 mL	16.7051 mL
20 mM	0.1671 mL	0.8353 mL	1.6705 mL	8.3525 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

6-Thioguanosine 6Thioguanosine 6 Thioguanosine

6-Thioguanosine

6-Thioguanosine

6-Thioguanosine 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词