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Anti-SIRP beta 1 Antibody (4S571)
还可以产品编号 TMAY-03477
Anti-SIRP beta 1 Antibody (4S571) 是一种 Rabbit 抗体，靶向 SIRP beta 1。Anti-SIRP beta 1 Antibody (4S571) 可用于 ELISA。
Anti-SIRP beta 1 Antibody (4S571)
Anti-SIRP beta 1 Antibody (4S571)
还可以产品编号 TMAY-03477
Anti-SIRP beta 1 Antibody (4S571) 是一种 Rabbit 抗体，靶向 SIRP beta 1。Anti-SIRP beta 1 Antibody (4S571) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-SIRP beta 1 Antibody (4S571) is a Rabbit antibody targeting SIRP beta 1. Anti-SIRP beta 1 Antibody (4S571) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4S571 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIRPB1A (rM SIRPB1A; TMPY-02388; BAD26610.1; Met1-Lys363). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.s |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse SIRPB1A protein (TMPY-02388) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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