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别名 NIAD4
NIAD-4是一种靶向amyloid-beta的近红外(NIR)荧光标记物(Ki=10 nM),能够穿透血脑屏障,可用于阿尔茨海默病的中枢神经系统(CNS)中Aβ光学成像的荧光团,吸收峰为475~480 nM。


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NIAD-4是一种靶向amyloid-beta的近红外(NIR)荧光标记物(Ki=10 nM),能够穿透血脑屏障,可用于阿尔茨海默病的中枢神经系统(CNS)中Aβ光学成像的荧光团,吸收峰为475~480 nM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 378 | 现货 | |
| 5 mg | ¥ 892 | 现货 | |
| 10 mg | ¥ 1,360 | 现货 | |
| 25 mg | ¥ 2,650 | 现货 | |
| 50 mg | ¥ 3,980 | 现货 |
NIAD-4 相关产品
| 产品描述 | NIAD-4 is a near-infrared (NIR) fluorescent label targeting amyloid-beta (Ki=10 nM) capable of crossing the blood-brain barrier. It serves as a fluorophore for optical imaging of Aβ in the central nervous system (CNS) for Alzheimer's disease, with absorption peaks at 475–480 nm. |
| 体外活性 | NIAD-4 可通过结合淀粉样蛋白聚集体、阻碍其内部旋转的方式提升荧光量子产率与荧光强度,是检测淀粉样蛋白的有效工具。NIAD-4因电荷中性且分子量低,能够穿透血脑屏障,可用于脑内淀粉样蛋白原纤维的成像。NIAD-4的激发波长为 475 nM,发射波长为 610 nM [2][3]。 |
| 别名 | NIAD4 |
| 分子量 | 334.42 |
| 分子式 | C18H10N2OS2 |
| CAS No. | 868592-56-7 |
| Smiles | N#CC(C#N)=CC=1SC(=CC1)C=2SC(=CC2)C=3C=CC(O)=CC3 |
| 颜色 | Red |
| 物理性状 | Solid |
| 存储 | keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度信息 | Ethanol: 0.2 mg/mL (0.6 mM), Sonication is recommended. DMSO: 20 mg/mL (59.81 mM), Sonication is recommended. DMSO:PBS(pH 7.2) (1:2): 0.3 mg/mL (0.9 mM), Sonication is recommended. DMF: 25 mg/mL (74.76 mM), Sonication is recommended. |
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