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Anti-CD3 zeta/CD247 Antibody (4V394)
还可以产品编号 TMAY-02501
Anti-CD3 zeta/CD247 Antibody (4V394) 是一种 Mouse 抗体，靶向 CD3 zeta/CD247。Anti-CD3 zeta/CD247 Antibody (4V394) 可用于 FCM。
Anti-CD3 zeta/CD247 Antibody (4V394)
Anti-CD3 zeta/CD247 Antibody (4V394)
还可以产品编号 TMAY-02501
Anti-CD3 zeta/CD247 Antibody (4V394) 是一种 Mouse 抗体，靶向 CD3 zeta/CD247。Anti-CD3 zeta/CD247 Antibody (4V394) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-CD3 zeta/CD247 Antibody (4V394) is a Mouse antibody targeting CD3 zeta/CD247. Anti-CD3 zeta/CD247 Antibody (4V394) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 4V394 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD3 Zeta expression on human whole blood lymphocytes.The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human CD3 Zeta, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD3 zeta / CD247 (rh CD3 zeta / CD247; TMPY-02960; P20963-1; Arg52-Arg164). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | FITC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human CD3 zeta / CD247 Protein (TMPY-02960) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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