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顶部生物活性储存和溶解信息计算器

Anti-IFNAR1 Antibody (4A488)

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Anti-IFNAR1 Antibody (4A488)
产品编号 TMAY-03308
别名 interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1

Anti-IFNAR1 Antibody (4A488) 是一种 Rabbit 抗体，靶向 IFNAR1。Anti-IFNAR1 Antibody (4A488) 可用于 ICC/IF。

Anti-IFNAR1 Antibody (4A488)
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Anti-IFNAR1 Antibody (4A488)

Rating icon 还可以
Anti-IFNAR1 Antibody (4A488)
产品编号 TMAY-03308 别名 interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1

Anti-IFNAR1 Antibody (4A488) 是一种 Rabbit 抗体，靶向 IFNAR1。Anti-IFNAR1 Antibody (4A488) 可用于 ICC/IF。

规格价格库存数量
20 μL
¥ 780
5日内发货
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-IFNAR1 Antibody (4A488) is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Antibody (4A488) can be used in ICC/IF.
别名interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1
Ig Type
Rabbit IgG
克隆号
4A488
交叉反应
Mouse
验证活性
Immunofluorescence staining of mouse IFNAR1 in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse IFNAR1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 594-conjugated Goat Anti-rabbit IgG secondary antibody (red) and counterstained with DAPI (blue).
应用
ICC/IF
推荐剂量
ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNAR1 (rM IFNAR1; TMPY-01489; NP_034638.2; Met1-Thr429).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse IFNAR1 Protein (TMPY-01489)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

interferon (a, b and w) receptor 1

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4个月前
5.0
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