Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tat-beclin 1 acetate 是一种有效的自噬诱导剂,并与自噬的负调节因子 GAPR-1 相互作用。 Tat-beclin 1 acetate 减少聚谷氨酰胺扩增蛋白聚集体的积累和几种病原体(包括 HIV-1)的复制。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 867 | 现货 | ||
5 mg | ¥ 1,930 | 现货 | ||
10 mg | ¥ 3,290 | 现货 | ||
25 mg | ¥ 5,390 | 现货 | ||
50 mg | ¥ 7,570 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,800 | 现货 |
产品描述 | Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1. Tat-beclin 1 acetate decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1). |
体外活性 | Tat-beclin 1 acetate (10 μM; 2-4 hours post-infection) decreases the intracellular survival of L. monocytogenes in primary murine bone-marrow-derived macrophages (BMDMs)[1]. Tat-beclin 1 acetate (10, 30, 50 μM; 24 hours) induces autophagy and results in a dose-dependent decrease in amounts of p62, a selective autophagy substrate, and a dose-dependent conversion of the non-lipidated form of LC3, LC3-I, to the lipidated, autophagosome-associated form of LC3, LC3-II, in multiple cell lines and primary murine embryonic fibroblasts (MEFs)[1]. |
体内活性 | Tat-beclin 1 acetate reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV). Tat-beclin 1 acetate (15 mg/kg; i.p.) induces autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice[1]. |
别名 | Tat-beclin 1 acetate(1423821-88-8 free base) |
分子量 | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.00mg/ml
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tat-beclin 1 acetate Autophagy Microbiology/Virology Proteases/Proteasome HIV Protease Tat beclin 1 acetate Tat-beclin 1 Acetate Tatbeclin 1 acetate Tat-beclin 1 acetate(1423821-88-8 free base) Inhibitor inhibitor inhibit