规格

价格

库存

数量

2 mg

¥ 1,830

现货

生物活性

产品描述	Integrin modulator 1 is a potent and selective α4β1 integrin agonist with an IC50 value of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 enhances cell adhesion mediated by α4β1 integrin with an EC50 of 12.9 nM, highlighting its utility in studying integrin-dependent adhesion processes.
靶点活性	α4β1:9.8 nM
体外活性	Integrin modulator 1（2-10 μg/mL；30分钟）能显著增强Jurkat E6.1细胞的黏附能力。Integrin modulator 1（1-100 nM；1小时）可强力且显著提升Jurkat E6.1细胞中ERK1/2的磷酸化水平[1]。Integrin modulator 1（1 nM-10 μM；30分钟）以浓度依赖的方式，显著增加HUTS-21抗体与Jurkat E6.1细胞的结合。[1]

化学信息

分子量	262.26
分子式	C₁₃H₁₄N₂O₄
CAS No.	2023788-32-9
Smiles	O=C(O)CC1N(C(=O)NC=2C=CC=CC2C)C(=O)C1
密度	1.413 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (305.04 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (19.07 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8130 mL	19.0650 mL	38.1301 mL	190.6505 mL
5 mM	0.7626 mL	3.8130 mL	7.6260 mL	38.1301 mL
10 mM	0.3813 mL	1.9065 mL	3.8130 mL	19.0650 mL
20 mM	0.1907 mL	0.9533 mL	1.9065 mL	9.5325 mL
50 mM	0.0763 mL	0.3813 mL	0.7626 mL	3.8130 mL
100 mM	0.0381 mL	0.1907 mL	0.3813 mL	1.9065 mL