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顶部相关产品产品介绍化学信息储存和溶解信息计算器

1-beta-D-Arabinofuranosylthymine

Synonyms: 阿糖胸苷, Thymine 1-β-D-arabinofuranoside, Spongothymidine
货号 TNU0352Cas号 605-23-2 一键复制产品信息纯度: 98.37%
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1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.

1-beta-D-Arabinofuranosylthymine

一键复制产品信息
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纯度: 98.37%

货号 TNU0352Cas号 605-23-2

别名 阿糖胸苷, Thymine 1-β-D-arabinofuranoside, Spongothymidine

1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.

1-beta-D-Arabinofuranosylthymine
规格价格库存数量
1 mg
¥ 446
现货
5 mg
¥ 1,090
现货
10 mg
¥ 1,650
现货
25 mg
¥ 2,730
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50 mg
¥ 3,930
现货
100 mg
¥ 5,370
现货
200 mg
¥ 7,230
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纯度: 98.37%
颜色: 白色
性状: Solid
资源下载: COA LCMS HNMR产品操作手册

产品介绍

1-beta-D-Arabinofuranosylthymine AI Summary
1-beta-D-Arabinofuranosylthymine exhibits broad-spectrum antiviral and inhibitory activities against various kinases and viruses. It shows significant inhibition of thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis with a Ki value of 238,000 nM. The compound effectively reduces plaque formation of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella zoster virus (VZV), and displays no detectable cytotoxicity in human embryonic lung fibroblast (HELF) cell cultures. It demonstrates in vitro cytotoxicity against HSV-1 HF strain in infected KB cells, with an IC50 value greater than 500.0 µg/mL and a therapeutic index of 833.0, indicating high selectivity for viral inhibition over cytotoxicity. Additionally, 1-beta-D-Arabinofuranosylthymine shows potent inhibition of HSV1 thymidine kinase (TK) with an IC50 of 24,000.0 nM, VZV TK with an IC50 of 17,000.0 nM, and moderate inhibition of Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) with an IC50 of 65,000.0 nM. The compound also exhibits cytotoxic activity against various tumor cell lines and has varied cytotoxic effects on mouse cell lines L1210/0 and S180, as well as human HL-60 cells, indicating its potential as a therapeutic agent with distinct antiviral and antitumor properties..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.
别名
阿糖胸苷, Thymine 1-β-D-arabinofuranoside, Spongothymidine
化学信息
分子量258.23
分子式C10H14N2O6
CAS No.605-23-2
SmilesO[C@@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(C)=C2
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

实际储存温度请以COA为准

溶解度信息
DMSO: 55 mg/mL (212.99 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.8725 mL19.3626 mL38.7252 mL193.6258 mL
5 mM0.7745 mL3.8725 mL7.7450 mL38.7252 mL
10 mM0.3873 mL1.9363 mL3.8725 mL19.3626 mL
20 mM0.1936 mL0.9681 mL1.9363 mL9.6813 mL
50 mM0.0775 mL0.3873 mL0.7745 mL3.8725 mL
100 mM0.0387 mL0.1936 mL0.3873 mL1.9363 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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