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Arachidonoyl-L-carnitine (chloride)

Arachidonoyl-L-carnitine (chloride)

产品编号 T37407
别名: C20:4 Carnitine​, Arachidonoyl-L-carnitine (chloride)

Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alterations in metabolic state.[1] [2] Arachidonoyl-L-carnitine formed from carnitine conjugated to arachidonic acid .

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T37407
Arachidonoyl-L-carnitine (chloride), CAS N/A
规格 价格/CNY 货期 数量
10 mg ¥ 371 待询
25 mg ¥ 906 待询
50 mg ¥ 1,287 待询
药物设计专题培训
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BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: Arachidonoyl-L-carnitine (chloride) (T37407)
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参考文献
产品描述 Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alterations in metabolic state.[1] [2] Arachidonoyl-L-carnitine formed from carnitine conjugated to arachidonic acid .
别名 C20:4 Carnitine​, Arachidonoyl-L-carnitine (chloride)
分子量 N/A

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 30 mg/mL

DMF: 20 mg/mL

DMSO: 10 mg/mL

PBS (pH 7.2): 10 mg/mL

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TargetMol Library Books参考文献

1. Osmundsen, H., Cervenka, J., and Bremer, J. A role for 2,4-enoyl-CoA reductase in mitochondrial β-oxidation of polyunsaturated fatty acids. Effects of treatment with clofibrate on oxidation of polyunsaturated acylcarnitines by isolated rat liver mitochondria. Biochemistry Journal 208(3), 749-757 (1982). 2. Sampey, B.P., Freemerman, A.J., Zhang, J., et al. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One 7(6), e38812 (2012).

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请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Arachidonoyl-L-carnitine (chloride) C20:4 Carnitine​ C20:4 Carnitine Arachidonoyl L carnitine (chloride) Arachidonoyl-L-carnitine ArachidonoylLcarnitine (chloride) Inhibitor inhibitor inhibit

 

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