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Leukotriene C4 methyl ester

Leukotriene C4 methyl ester

产品编号 T37620   CAS 73958-10-8

Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM. LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.

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Leukotriene C4 methyl ester Chemical Structure
Leukotriene C4 methyl ester, CAS 73958-10-8
规格 价格/CNY 货期 数量
25 μg ¥ 2,520 35日内发货
50 μg ¥ 4,790 35日内发货
100 μg ¥ 8,900 35日内发货
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BCA蛋白浓度测定试剂盒限时半价
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产品目录号及名称: Leukotriene C4 methyl ester (T37620)
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存储 & 溶解度
产品描述 Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM. LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.
分子量 639.81
分子式 C31H49N3O9S
CAS No. 73958-10-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

PBS (pH 7.2): 0.15 mg/mL

Ethanol: 1 mg/mL

DMF: 50 mg/mL

DMSO: 50 mg/mL

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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

Leukotriene C4 methyl ester 73958-10-8 Leukotriene C-4 methyl ester Inhibitor inhibitor inhibit

 

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