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Anti-ER beta Antibody (4M551)
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产品编号 TMAY-00093
Anti-ER beta Antibody (4M551) 是一种 Mouse 抗体，靶向 ER beta。Anti-ER beta Antibody (4M551) 可用于 ICC/IF。
Anti-ER beta Antibody (4M551)
Anti-ER beta Antibody (4M551)
还可以产品编号 TMAY-00093
Anti-ER beta Antibody (4M551) 是一种 Mouse 抗体，靶向 ER beta。Anti-ER beta Antibody (4M551) 可用于 ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ER beta Antibody (4M551) is a Mouse antibody targeting ER beta. Anti-ER beta Antibody (4M551) can be used in ICC/IF. |
| Ig Type | Mouse IgG1 |
| 克隆号 | 4M551 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of ER beta in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human ER beta monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green). Positive staining was localized to Nucleus. |
| 应用 | |
| 推荐剂量 | ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human ER beta/ESR2. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. A number of association studies have focused on ESR2 polymorphisms to investigate the relationship with cancer risk. The development of endometriosis is associated with changes in the expression of genes encoding the 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) and 17beta-hydroxysteroid dehydrogenase type II (HSD17B2), estrogen receptors 1 (ESR1) and 2 (ESR2) and the androgen receptor (AR). Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation, that ESR2 regulates key genes in GCs that are essential for follicle maturation and ovulation in the rat. There is a strong association between ESR2 SNPs and BMD, indicating that ESR2 may influence attainment of bone mass. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: C-terminus of the Human ER beta/ESR2 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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