规格

价格

库存

数量

50 mg

¥ 99

现货

1 mL x 10 mM (in DMSO)

¥ 413

现货

生物活性

产品描述	Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.
靶点活性	CA:10 nM
体外活性	acetazolamide reduces invasiveness of cancer cells in vitro[3].
体内活性	Acetazolamide reduces inflammation-induced heat hyperalgesia, probably acting both peripherally and centrally[1]. Acetazolamide shows significant inhibitory effect on angiogenesis in CAM and endothelial cell proliferation[2]. Acetazolamide is clinically used to reduce intraocular pressure in glaucoma, to correct metabolic alkalosis, and to manage cerebral edema. Its treatment may also be beneficial as an adjunct to cancer chemotherapy, because it can produce additive tumor growth delays with anticancer drugs in vivo[3].
细胞实验	The invasion assay is performed in a Biocoat Matrigel invasion chamber. Cells (n = 1.8 × 105) are added to the chamber and cultured for 48 h in the presence or absence of acetazolamide, which was administered twice during the 48-h period: the first dose at the beginning of the assay and the second after 24 h. After growing for 48 h, noninvasive cells are removed from the upper surface of the membrane with a cotton swab. The invasive cells on the lower surface of the membrane are fixed with 4% (vol/vol) neutral-buffered formaldehyde, stained with toluidine blue, and counted in 20 separate areas with a Leitz Diaplan microscope. (Only for Reference)
别名	乙酰唑胺, Diamox

化学信息

分子量	222.25
分子式	C₄H₆N₄O₃S₂
CAS No.	59-66-5
Smiles	CC(=O)NC1=NN=C(S1)S(N)(=O)=O
密度	1.610 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Ethanol: <1 mg/mL

DMSO: 84.17 mg/mL (378.72 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4994 mL	22.4972 mL	44.9944 mL	224.9719 mL
5 mM	0.8999 mL	4.4994 mL	8.9989 mL	44.9944 mL
10 mM	0.4499 mL	2.2497 mL	4.4994 mL	22.4972 mL
20 mM	0.2250 mL	1.1249 mL	2.2497 mL	11.2486 mL
50 mM	0.0900 mL	0.4499 mL	0.8999 mL	4.4994 mL
100 mM	0.0450 mL	0.2250 mL	0.4499 mL	2.2497 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Acetazolamide

Acetazolamide

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Acetazolamide

Acetazolamide

Acetazolamide 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词