Name: NADH disodium hydrate
Brand: TargetMol
SKU: T86953
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

5日内发货

50 mg

待询

5日内发货

生物活性

产品描述	NADH disodium salt hydrate, also known as Disodium NADH hydrate, functions as an orally active reduced coenzyme. It serves as a donor of ADP-ribose units in ADP-ribosylation reactions and acts as a precursor to cyclic ADP-ribose. Additionally, it contributes to cellular energy metabolism by acting as a renewable electron donor in processes such as glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle [1].
体外活性	NADH is stable under alkaline conditions but unstable under acidic conditions [2]. At concentrations of 0-1 mM over 0-12 hours, NADH increases NAD+ levels in various mammalian cell lines [3]. Additionally, NADH at 1 mM for 24 hours exhibits low toxicity and protects cells from genotoxicity [3].
体内活性	NADH, administered intraperitoneally at 5 μmol/mouse, enhances urinary excretion of nicotinamide and its metabolites in male ICR mice [2]. At a dosage of 500 mg/kg, orally administered NADH promotes alcohol metabolism and protects against early liver injury from acute alcohol exposure in male C57BL/6J mice by modulating blood acetaldehyde levels and maintaining the NAD+/NADH redox balance [3]. Additionally, a 1000 mg/kg intraperitoneal dose of NADH increases tissue NAD+ levels in these mice [3].
别名	Disodium NADH hydrate

化学信息

分子量	709.4
分子式	C₂₁H₂₉N₇O₁₄P₂.xH₂O.2Na
CAS No.	1949720-50-6
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)N5C=C(C(N)=O)CC=C5)(=O)O)(=O)O)[C@H]1O.[Na].O