- 全部删除
- 您的购物车当前为空
Thioacetamide(TAA)是一种间接性肝毒剂,常用于诱导实验性肝损伤。TAA 经 CYP2E1 代谢生成活性代谢物,与蛋白质和脂质共价结合,引发氧化应激和小叶中央坏死,导致肝细胞坏死及以 M1/M2 巨噬细胞为主的炎症反应,常用于构建慢性肝纤维化和肝性脑病以及肝癌模型。
Thioacetamide(TAA)是一种间接性肝毒剂,常用于诱导实验性肝损伤。TAA 经 CYP2E1 代谢生成活性代谢物,与蛋白质和脂质共价结合,引发氧化应激和小叶中央坏死,导致肝细胞坏死及以 M1/M2 巨噬细胞为主的炎症反应,常用于构建慢性肝纤维化和肝性脑病以及肝癌模型。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 g | ¥ 108 | In stock | |
25 g | ¥ 475 | In stock | |
1 mL x 10 mM (in DMSO) | ¥ 185 | In stock |
产品描述 | Thioacetamide (TAA) is an indirect hepatotoxin commonly used to induce experimental liver injury. It is metabolized by CYP2E1 into reactive metabolites that covalently bind to proteins and lipids, leading to oxidative stress and centrilobular necrosis, hepatocyte death, and M1/M2 macrophage-dominated inflammation. TAA is widely used to establish models of chronic liver fibrosis, hepatic encephalopathy, and liver cancer. |
别名 | 硫代乙酰胺, TAA |
分子量 | 75.13 |
分子式 | C2H5NS |
CAS No. | 62-55-5 |
Smiles | CC(S)=N |
密度 | 1.37 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (732.06 mM), Sonication is recommended. ![]() H2O: 16.3 g/100 mL (25 oC), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
|
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
评论内容