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Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody
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产品编号 TMAC-03329
别名 p-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641)
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKC beta (Thr641)。Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody 可用于 WB,IHC,IF。
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody
还可以产品编号 TMAC-03329 别名 p-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641)
Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKC beta (Thr641)。Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody 可用于 WB,IHC,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,230 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC beta (Thr641). Anti-Phospho-PKC beta (Thr641) Polyclonal Antibody can be used in WB,IHC,IF. |
| 别名 | p-PKC beta (Thr641), p-PKC beta (T641), PKC beta (p-Thr641), PKC beta (p-T641) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using PKCb (phospho-Thr641) antibody (TMAC-03329). 2. Immunofluorescence staining of methanol-fixed MCF7 cells using PKCb (phospho-Thr641) antibody (TMAC-03329, Red). 3. Western blot analysis of extracts from JK cells untreated or treated with PMA using PKCβ (phospho-Thr641) antibody TMAC-03329. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKCb |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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