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CD122/IL2RB Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-05784

别名: IL-15Rβ, Il-2/15Rbeta, Il-2Rβ, interleukin 2 receptor, β, IL-15Rbeta, interleukin 2 receptor, beta, Il-2Rbeta, CD122, p70, IL15Rβ, Il-2/15Rβ, IL15Rbeta

CD122/IL2RB Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.76 kDa and the accession number is P16297.

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CD122/IL2RB Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 6,420		现货
200 μg	￥ 10,700		5日内发货
500 μg	￥ 20,980		5日内发货

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生物活性	Testing in progress
产品描述	CD122/IL2RB Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.76 kDa and the accession number is P16297.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P16297
别名	IL-15Rβ, Il-2/15Rbeta, Il-2Rβ, interleukin 2 receptor, β, IL-15Rbeta, interleukin 2 receptor, beta, Il-2Rbeta, CD122, p70, IL15Rβ, Il-2/15Rβ, IL15Rbeta
蛋白构建	The Mouse IL2RB (NP_032394.1) (Met1-Glu240) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	51.76 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-2 receptor (IL-2R) also known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms concerning the ability to bind interleukin 2. The low-affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high-affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high-affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.

参考文献

1. Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6. 2. Sprent J, et al. (2001) T cell death and memory. Science. 293(5528): 245-8. 3. Teshigawara K, et al. (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 165 (1): 223-38.

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Keywords

CD122/IL2RB Protein, Mouse, Recombinant (hFc) IL-15Rβ Il-2/15Rbeta Il-2Rβ CD-122 CD 122 interleukin 2 receptor, β IL-15Rbeta interleukin 2 receptor, beta Il-2Rbeta CD122 p70 IL15Rβ Il-2/15Rβ IL15Rbeta recombinant recombinant-proteins proteins protein

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