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GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

产品编号 TMPJ-00290
别名: TRNR2, GDNFR-beta, TGF-β-related neurotrophic factor receptor 2, GDNFRB, RET ligand 2, RETL2, Neurturin receptor alpha, TGF-beta-related neurotrophic factor receptor 2, GDNFR-β, Neurturin receptor α

GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.

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GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)
规格 价格/CNY 货期 数量
10 μg ¥ 380 5日内发货
50 μg ¥ 820 5日内发货
500 μg ¥ 5,130 5日内发货
1 mg ¥ 8,300 5日内发货
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产品目录号及名称: GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) (TMPJ-00290)
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产品性质
产品描述 GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc-6xHis
蛋白编号 O00451
别名 TRNR2, GDNFR-beta, TGF-β-related neurotrophic factor receptor 2, GDNFRB, RET ligand 2, RETL2, Neurturin receptor alpha, TGF-beta-related neurotrophic factor receptor 2, GDNFR-β, Neurturin receptor α
氨基酸序列 Ser22-Ser441
蛋白构建 Ser22-Ser441
分子量 120 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.

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Keywords

GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) TRNR2 GDNFR-beta TGF-β-related neurotrophic factor receptor 2 GDNFRB RETL-2 RET ligand 2 RETL2 Neurturin receptor alpha TGF-beta-related neurotrophic factor receptor 2 GDNFR-β RETL 2 TRNR 2 TRNR-2 TGF-b-related neurotrophic factor receptor 2 Neurturin receptor α recombinant recombinant-proteins proteins protein

 

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