Nebularine

Name: Nebularine
Brand: TargetMol
SKU: TNU0052
Price: 166 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.59%

货号 TNU0052Cas号 550-33-4

别名 水粉蕈素, 9-(beta-D-Ribofuranosyl)-9H-purine

Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine)，是一种嘌呤核苷类似物，具有广谱的抗肿瘤活性，针对惰性淋巴恶性肿瘤并诱导凋亡。Nebularine的抗癌机制依赖于抑制DNA合成。

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Nebularine

一键复制产品信息

很棒

纯度: 99.59%

货号 TNU0052 别名 水粉蕈素, 9-(beta-D-Ribofuranosyl)-9H-purineCas号 550-33-4

规格	价格	库存
1 mg	¥ 166	现货
5 mg	¥ 363	现货
10 mg	¥ 579	现货
25 mg	¥ 928	现货
50 mg	¥ 1,390	现货
100 mg	¥ 1,980	现货

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产品介绍

Nebularine AI Summary

Nebularine demonstrates a diverse range of biological activities. It exhibits potent anti-Herpes simplex virus type-1 activity in vero cells with an IC50 of 0.6 nM, effectively inhibiting viral replication. In mouse models, it shows significant antitumor effects against P388 tumors, with an increase in lifespan of 40.0% at 6.25 mg/kg and 60.0% at 3.13 mg/kg. Additionally, it displays differential inhibitory activity across various enzymes and cells. It inhibits mouse kidney cytidine deaminase with a Ki of 10000.0 nM and adenosine deaminase enzymes from calf intestine and calf duodenum with Ki values of 15000.0 nM and 9300.0 nM, respectively. Against mouse L929 cells, it shows cytotoxicity with an IC50 of 2370.0 nM, and it has trypanocidal activity against Trypanosoma brucei brucei with an IC50 of 1150.0 nM. Furthermore, it inhibits proliferation in various human tumor cell lines and affects multiple molecular targets, including ROR gamma, Lamin A, and Bloom's syndrome helicase, among others. Nebularine also exhibits potential as an inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP1) and may inhibit Marburg Virus and Lassa Virus entry into cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.The anticancer mechanism of Nebularine is dependent on the inhibition of DNA synthesis.
别名	水粉蕈素, 9-(beta-D-Ribofuranosyl)-9H-purine

化学信息

分子量	252.23
分子式	C₁₀H₁₂N₄O₄
CAS No.	550-33-4
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cncnc12
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (218.05 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9646 mL	19.8232 mL	39.6464 mL	198.2318 mL
5 mM	0.7929 mL	3.9646 mL	7.9293 mL	39.6464 mL
10 mM	0.3965 mL	1.9823 mL	3.9646 mL	19.8232 mL
20 mM	0.1982 mL	0.9912 mL	1.9823 mL	9.9116 mL
50 mM	0.0793 mL	0.3965 mL	0.7929 mL	3.9646 mL
100 mM	0.0396 mL	0.1982 mL	0.3965 mL	1.9823 mL